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The Poor COVID-19 Outcomes and Abnormal Liver Tests Have a Connection – Crucial Insights to Consider




The COVID-19 disease gets caused by the novel coronavirus, where the symptoms are linked with ageusia, shortness of breath, sore throat, anosmia, nasal congestion, and aches in the body. Some people also get prone to diarrhea, vomiting, and nausea. Even though the symptoms stay mild for most cases, older adults have an increased risk of a fatal disease accompanied with a coronary heart ailment, diabetes, and hypertension.

Vaccines seem to be the only way of getting immune from the virus. According to MyBioSource, Americans are propagating the concept of paid immunity. They think that people who haven’t taken the vaccine should get $182 for getting vaccinated. The amount for this for the people in Delaware is $131.

The liver and the virus

Even though the pre-existing liver ailment hasn’t been listed in the earlier studies, the increased ALT (alanine aminotransferase) levels, less platelet counts and minimized albumin levels while getting admitted have been linked with increased mortality. Hence, today it is still unclear if all the lab test changes signal liver ailment in patients who got severely infected, regardless of highlighting liver damage due to the virus or any other extreme inflammatory response. Patients with advanced chronic liver ailment have a risk factor because of the dysfunction caused by cirrhosis. The same can get considered true for the patients post-liver transplantation, especially the ones with autoimmune liver ailments who take immunosuppressive therapies.

But today, there is minimal data concerning this deadly virus and the liver ailment. You will find acute hepatitis B infection is present in China. One still needs to gather proof that immunosuppression can offer a certain degree of security from immunopathology, which can contribute to lung damage where there are more disease manifestations. It can get linked with the macrophage activation syndrome when you are linking it with the hyperinflammatory syndrome featured by the cytokine storm along with several organ failure. However, the systemic viral infections are usually connected with the temporary increase in the transaminases that can denote inflammation owing to circulating cytokines without any liver function compromise.

There is a chance that COVID-19 infection can affect the liver cells because the angiotensin-converting enzyme 2 can get expressed on the angiotensin-converting enzyme 2, that can demonstrate the reason for viral shedding in feces. However, there still needs to be ample research to confirm this fact, which is possible only through increased clinical trials.

Other than the direct liver disease implications on the pandemic and vice versa, there are many extra aspects that need attention. The present pandemic and the percentage of the available data, comprising the rumors and misinformation, lead to uncertainties and concerns amidst the patients and healthcare providers. The liver ailments are very much prevalent in the population of the United States. According to Dr. Michael Nathanson, about one-third of the people who reside in the United States suffer from fatty liver disease. Many others suffer from acute hepatitis C or B.

A ray of hope to cure liver ailments because of the COVID-19 virus

Today, Yale University researchers have studied about the coronavirus and its implications on human health. And as they conducted several studies, they also had access to several health records of the patients, who could have access to liver tests before getting affected by the deadly virus. Nearly one-quarter of the patients under observation witnessed abnormal liver tests before getting affected by the virus. However, irrespective of the fact whether the patients arrived at the hospital already suffering from liver problems or had developed them because of the COVID-19 infection or hospitalization, there was a strong link that got established between the extreme cases of the COVID-19 infection and abnormal liver tests.

Instead of the liver generating poor outcomes in the COVID-19 patients, it is noticed that the organ gets considered as the bystander, impacted by the hyperinflammation linked with the pandemic and the side effects of the associated treatments. Several studies have highlighted the link between the drugs used for treating acute COVID-19 and sudden liver damage. One of the drugs that got noticed majorly for this is tocilizumab.

According to several medical experts, there is a strong link between the medications used to treat COVID-19 and abnormal liver tests. However, one can’t say for certain that liver issues always originated from the drug. There are times when a patient with an existing liver condition often witnesses an aggravation in their liver health because of the virus infection. In such a situation, one must consider that the novel coronavirus is notoriously worsening the already existing health and liver problems in people. Hence, the best way to treat this is by assessing the entire liver condition of the patient and checking whether it can get reverse. Alternatively, attempts should be taken to see how much benefit the medicines can bring to the patient.



Sujain Thomas is a contributing author of H2hub. She has been passionate about watches like Emporio Armani watch, since childhood. Although being raised in the digital watch era, she found her way to mechanical timepieces. After being active on watch forums from the 1990s onwards, she decided to start a blog on watches in 2004. Nowadays her main focus is on Emporio Armani watch